New signal processing theories, models, and algorithms are needed to address the growing demand for new imaging capabilities that exceed physical limits or constraints. Our research derives new image and measurement models and combines these learned models with new, computationally efficient algorithms suitable for practical use. Doctors will be able to study and diagnose diseases in living subjects at greater levels of detail, revealing new insights and improving accuracy. Microscopes will be able to locate and track molecules and cells in three dimensions with unprecedented precision. Our lab envisions a future where computational imaging allows us to observe the presently unobservable.